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Michio Hirano Selected Research
Michio Hirano Research Topics
Disease
44
Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 11/2002
26
Muscular Diseases (Myopathy)
01/2020 - 09/2002
10
Cerebellar Ataxia (Dysmetria)
11/2019 - 01/2003
9
Mitochondrial Myopathies (Mitochondrial Myopathy)
01/2022 - 07/2003
8
Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)
10/2016 - 09/2002
8
Coenzyme Q10 Deficiency
03/2013 - 02/2006
8
Lactic Acidosis
02/2013 - 03/2005
6
MELAS Syndrome (Syndrome, MELAS)
01/2022 - 03/2005
5
Ataxia (Dyssynergia)
11/2019 - 03/2008
5
Atrophy
08/2014 - 01/2003
5
Brain Diseases (Brain Disorder)
05/2014 - 05/2007
4
Muscle Hypotonia (Hypotonia)
01/2019 - 06/2008
4
Neurodegenerative Diseases (Neurodegenerative Disease)
04/2017 - 09/2006
4
Muscle Weakness
01/2017 - 09/2012
3
Disease Progression
01/2022 - 11/2011
3
Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2021 - 03/2008
3
Spinal Muscular Atrophy (Progressive Muscular Atrophy)
01/2021 - 01/2003
3
Dystonia (Limb Dystonia)
11/2019 - 05/2007
3
Cardiomyopathies (Cardiomyopathy)
01/2019 - 01/2017
3
Leigh Disease (Leigh's Disease)
10/2018 - 12/2006
3
Cytochrome-c Oxidase Deficiency
01/2018 - 11/2002
3
Liver Failure
01/2018 - 09/2002
3
Visceral myopathy familial external ophthalmoplegia
10/2015 - 03/2003
3
Peripheral Nervous System Diseases (PNS Diseases)
10/2015 - 09/2006
3
Diabetes Mellitus
12/2014 - 01/2005
3
Nephrotic Syndrome (Syndrome, Nephrotic)
07/2014 - 12/2006
3
Muscular Dystrophies (Muscular Dystrophy)
05/2013 - 01/2002
3
MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers)
09/2011 - 05/2003
3
Kearns-Sayre Syndrome
01/2007 - 09/2002
3
Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy)
04/2005 - 01/2004
2
Rare Diseases (Rare Disease)
10/2021 - 01/2021
2
Respiratory Insufficiency (Respiratory Failure)
11/2019 - 01/2018
2
Heart Failure
04/2017 - 01/2016
2
Deafness (Deaf Mutism)
01/2017 - 04/2002
2
Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
11/2016 - 05/2013
2
Heart Diseases (Heart Disease)
01/2016 - 05/2003
2
Neutral Lipid Storage Disease with Myopathy
09/2012 - 03/2009
2
Myoglobinuria
04/2011 - 05/2010
2
Chanarin-Dorfman Syndrome
06/2010 - 03/2009
2
Seizures (Absence Seizure)
05/2009 - 06/2008
2
Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
05/2009 - 05/2003
2
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
03/2009 - 08/2007
2
Myasthenia Gravis
01/2009 - 01/2003
2
Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction)
10/2008 - 03/2006
2
Infections
05/2007 - 09/2006
1
Ophthalmoplegia (External Ophthalmoplegia)
01/2022
1
autosomal recessive 1 Spinocerebellar ataxia
01/2021
Drug/Important Bio-Agent (IBA)
59
Mitochondrial DNA (mtDNA)
IBA
01/2022 - 04/2002
19
coenzyme Q10 (CoQ10)
IBA
11/2019 - 01/2003
12
Proteins (Proteins, Gene)
FDA Link
01/2021 - 04/2005
11
DNA (Deoxyribonucleic Acid)
IBA
01/2021 - 01/2004
7
Ubiquinone
IBA
08/2012 - 03/2008
6
Electron Transport Complex IV (Cytochrome c Oxidase)
IBA
08/2014 - 05/2003
6
Nucleotides
IBA
05/2013 - 05/2003
5
Enzymes
IBA
01/2022 - 12/2006
5
Biomarkers (Surrogate Marker)
IBA
01/2020 - 09/2011
5
Mitochondrial Proteins (Mitochondrial Protein)
IBA
10/2016 - 06/2005
5
Leu Transfer RNA
IBA
03/2010 - 05/2003
4
Thymidine
IBA
10/2021 - 05/2014
4
Deoxyuridine
IBA
01/2016 - 03/2003
4
Lipids
IBA
09/2012 - 08/2007
3
Lactic Acid (Lactate)
FDA Link
Generic
01/2022 - 03/2008
3
thymidine kinase 2
IBA
10/2021 - 01/2011
3
Calcium
IBA
01/2020 - 01/2016
3
Thymidine Kinase
IBA
10/2019 - 07/2003
3
Adenosine Triphosphate (ATP)
IBA
10/2018 - 07/2003
3
Thymidine Phosphorylase
IBA
12/2014 - 03/2003
3
Phospholipids (Phosphatides)
FDA Link
Generic
08/2013 - 04/2005
3
Creatine Kinase (Creatine Phosphokinase)
IBA
02/2013 - 03/2010
3
Transfer RNA (tRNA)
IBA
04/2011 - 05/2003
2
pyrimidine
IBA
10/2021 - 10/2019
2
RNA (Ribonucleic Acid)
IBA
01/2021 - 05/2003
2
2- cyclohexylidenhydrazo- 4- phenyl- thiazole
IBA
01/2021 - 03/2010
2
Phosphotransferases (Kinase)
IBA
01/2021 - 03/2008
2
Sirolimus (Rapamycin)
FDA Link
01/2021 - 12/2017
2
Growth Differentiation Factor 15
IBA
01/2020 - 11/2019
2
Succinate Dehydrogenase (Fumarate Reductase)
IBA
01/2018 - 05/2003
2
Guanine
IBA
04/2017 - 05/2003
2
Adenine
FDA Link
Generic
04/2017 - 05/2003
2
triphosphoric acid (triphosphate)
IBA
01/2016 - 05/2014
2
Fatty Acids (Saturated Fatty Acids)
IBA
04/2011 - 03/2010
2
Cytochromes b (Cytochrome b)
IBA
04/2011 - 03/2010
2
Ile Transfer RNA
IBA
04/2011 - 03/2010
2
Phosphoglycerate Kinase (Kinase, Phosphoglycerate)
IBA
05/2010 - 03/2010
2
Transferases
IBA
03/2010 - 02/2006
2
Acyl Coenzyme A (Acyl CoA)
IBA
03/2009 - 08/2007
2
Nucleosides
IBA
02/2009 - 07/2003
2
Linezolid (Zyvox)
FDA Link
05/2007 - 06/2005
1
Cytokines
IBA
01/2022
1
N-acetylaspartate (N-acetyl aspartate)
IBA
01/2022
1
Deoxycytidine
IBA
10/2021
1
Phosphatidylinositols (Phosphatidylinositol)
IBA
01/2021
1
bafilomycin A1
IBA
01/2021
1
Transcription Factors (Transcription Factor)
IBA
01/2021
1
gamma-Aminobutyric Acid (GABA)
IBA
01/2021
1
NAD (NADH)
IBA
01/2021
1
Proton-Translocating ATPases (ATPase, H+)
IBA
01/2021
1
Exoribonucleases
IBA
01/2021
Therapy/Procedure
17
Therapeutics
10/2021 - 01/2003
2
Stem Cell Transplantation
10/2015 - 11/2011